Antifungal Activity of the Saponin Fraction Obtained from Asparagus officinalis L. and Its Active Principle(Organic Chemistry)

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概要

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• Antifungal activity was detected in the crude saponin fraction obtained from the bottom cut of Asparagus officinalis L. This activity was specific to certain fungi, for example Candida, Cryptococcus, Trichophyton, Microsporum and Epidermophyton. Attempts were made to isolate the active principles from this fraction; in this way a new saponin (AS-1) was isolated, and its structure was estimated to be 3-O-[{β-D-glucopyranosyl(1→2)}{β-D-xylopyranosyI(1→4)-β-D-glucopyranosyl]-(25S),5β-spirostan-3β-ol. The minimum inhibitory concentration (MIC) ranged from 0.5μg/ml to more than 8μg/ml depending upon the nature of the fungi. On the basis of the work carried out here, it is probable that asparagus will contain additional antifungal principles.

• 社団法人日本農芸化学会の論文
• 1990-10-23

著者

• SHIMOYAMADA Makoto

  Department of Bioprocessing, Faculty of Agriculture, Gifu University

• OKUBO Kazuyoshi

  Department of Food Chemistry, Faculty of Agriculture, Tohoku University

• Sonta Hiromi

  Central Research Laboratory Dowa Mining Co. Ltd.

• SUZUKI Masayuki

  Central Research Laboratory, Dowa Mining Co., Ltd.

• MARUYAMA Makiko

  Central Research Laboratory, Dowa Mining Co., Ltd.

• Maruyama Makiko

  Central Research Laboratory Dowa Mining Co. Ltd.

• Okubo Kazuyoshi

  Department Of Applied Biological Chemistry Faculty Of Agriculture Tohoku University

• Shimoyamada Makoto

  Department Of Food Chemistry Faculty Of Agriculture Tohoku University

• Suzuki M

  Japan Atomic Energy Res. Inst. Kyoto Jpn

• Suzuki Masayuki

  Advanced Photon Research Center Kansai Research Establishment Japan Atomic Energy Research Institute

• Suzuki Masayuki

  Central Research Laboratories Tokyo Food Techno Co. Ltd.

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