Synthesis of (-)-Biopterin Using (S)-Ethyl Lactate as a Starting Material(Organic Chemistry)
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概要
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(-)-Biopterin was synthesized from (1S, 2S)-1-(1, 3-dithian-2-yl) propane-1, 2-diol 5 (=C), which was derived from commercially available (S)-ethyl lactate. Diol 5 (=C) was converted to 15 through a six-step sequence. Ketone 15 was submitted to condensation with 3, 5, 6-triaminopyrimidinol (TAP, 2), and followed by oxidation to afford isopropylidenebiopterin (16). Finally, 16 was deprotected to give (-)-biopterin (1).
- 社団法人日本農芸化学会の論文
- 1989-08-23
著者
-
Kikuchi Haruhiko
Department Of Agricultural Chemistry The University Of Tokyo
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Mori Kenji
Department Of Agricultural Chemistry Nagoya University
-
Mori Kenji
Department Of Agricultural Chemistry College Of Science And Technology The University Of Tokyo
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