Inhibition by Trichothecene Mycotoxins of Replication of Herpes Simplex Virus Type 2(Biological Chemistry)
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概要
- 論文の詳細を見る
The effects of the trichothecene mycotoxins diacetoxyscirpenol, neosolaniol and T-2 toxin on the replication of herpes simplex virus type 2 (HSV-2) in HEp-2 cells were examined. The 50% inhibitory concentrations for HSV-2 replication were 2.3 ng/ml for diacetoxyscirpenol, 52.0 ng/ml for neosolaniol, and 1.6ng/ml for T-2 toxin. The addition of these toxins to the cells within 4 hr after HSV-2 infection was necessary for the inhibition of the virus replication. Viral polypeptides synthesized in HSV-2-infected cells treated with the toxins were analyzed by immunoblotting using rabbit antiserum to HSV-2. The syntheses of early viral proteins were greatly inhibited when the toxins were added 1hr after infection, and those of late viral proteins were also inhibited by toxin exposures 4 hr through 6 hr after infection. The toxins added after the completion of the latter protein syntheses affected the HSV-2 replication insignificantly. However, viral RNA synthesis was not inhibited when the toxins were added 1hr after infection. These results indicate that trichothecene mycotoxins inhibit HSV-2 replication by blocking viral protein syntheses.
- 社団法人日本農芸化学会の論文
- 1988-03-23
著者
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YOSHIZAWA Takumi
Department of Biochemistry and Food Science, Kagawa Universitry
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OKAZAKI Katsuichiro
Department of Bioresource Science, Faculty of Agriculture, Kagawa University
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Kimura S
Tohoku Univ. Sendai Jpn
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Kimura S
Department Of Microbiology Kochi Medical School
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Yoshizawa Takumi
Department Of Biochemistry And Food Science Faculty Of Agriculture Kagawa University
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Kimura Susumu
Department Of Microbiology Kochi Medical School
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Okazaki K
Department Of Life Sciences Faculty Of Agriculture Kagawa University
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Okazaki Katsuichiro
Department Of Bioresource Science Faculty Of Agriculture Kagawa University
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Yoshizawa T
Kagawa Univ. Kagawa Jpn
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Yoshizawa T
Department Of Biochemistry And Food Science Faculty Of Agriculture Kagawa University
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Okazaki Katsuichiro
Department Of Applied Biological Science Faculty Of Agriculture Kagawa University
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KIMURA Susumu
Department of Bacteriology, School of Medicine, Toknshima University
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