Thymocyte Apoptosis by T-2 Toxin in Vivo in Mice Is Independent of Fas/Fas Ligand System
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概要
- 論文の詳細を見る
To find whether Fas/Fas ligand (FasL) pathway is involved in T-2 toxin (T-2)-mediated thymocyte apoptosis, we used lpr/lpr (lpr) and gld/gld (gld) mice, whose Fas and FasL proteins, respectively, are functionally deficient. Based on the DNA fragmentation profile in gel electrophoresis and measurement of apoptotic cell percent by flow cytometry, the levels of thymocyte apoptosis in lpr and gld mice that had received T-2 showed that both lpr and gld mice had undergone apoptosis essentially to the same magnitude as those of corresponding wild type mice (+/+). These results strongly suggest that T-2-induced thymocyte apoptosis in vivo in mice is independent of the Fas/FasL pathway.
- 社団法人日本農芸化学会の論文
- 2000-01-23
著者
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YOSHIZAWA Takumi
Department of Biochemistry and Food Science, Kagawa Universitry
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Yoshizawa Takumi
Department Of Biochemistry And Food Science Faculty Of Agriculture Kagawa University
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SAKATO Nobuo
Department of Plant Sciences, Faculty of Agriculture, Kagawa University
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Yoshizawa T
Kagawa Univ. Kagawa Jpn
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NAGASE Masahiro
Department of Life Sciences, Faculty of Agriculture, Kagawa University
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ALAM M.Murshedul
Department of Life Sciences, Faculty of Agriculture, Kagawa University
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Nagase M
Kagawa Univ. Kagawa Jpn
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Nagase Masahiro
Department Of Life Sciences Faculty Of Agriculture Kagawa University
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Sakato N
Ehime Univ. Ehime Jpn
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Yoshizawa T
Department Of Biochemistry And Food Science Faculty Of Agriculture Kagawa University
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Alam M.murshedul
Department Of Life Sciences Faculty Of Agriculture Kagawa University
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Sakato Nobuo
Department of Life Sciences, Faculty of Agriculture, Kagawa University
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