状態依存学習に及ぼすACTHの効果

概要

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The aim of this article is to explore the possibility that naturally occuring physiological change may cause so-called state-dependent learning. In following experiments ACTH (adrenocorticotrophic hormone) in low dose was used as agent which occure physiological change. Total three experiments were carried out using one trial passive avoidance task. Exp. I was designed to determine the appropriate shock level used in two-compartment apparatus. Exp. II was designed to examine the effect of ACTH on state-dependent learning in rats. 65 rats were randomly assigned to three groups (Group-A; 0.36mA×ACTH 0.2cc Group-B; 0.13mA×ACTH 0.2cc Group-C; 0.13mA×ACTH 0.3cc). Then experiment was performed following 2×2 typical SDL design. ACTH or saline were injected i.m. 2hr before acquisition and retention. Results obtained in this experiment showed no significant sign of SDL. In other word ACTH in low dose (0.2cc, 0.3cc) dose not cause SDL. In Exp. III precedure was basically the same as Exp. II except for injection route. In Exp. III ACTH was injected s.c. 2hr before acquisition and retention. Results also showed no significant sign of SDL.
横浜国立大学の論文
1982-10-30