2-lever型薬物弁別課題における学習プロセスの分析

概要

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The aim of this article is to attempt a solution of the problems that current typical drug discrimination methods involve. (1) Most of reports didn't describe the process of discrimination learning precisely. How dose drug discrimination learning proceed? (2) Both number of TR (Total Responses) and FFP (First Food Pellet) have been adopted as a learning criterion. Which measure is more valid to describe the drug discrimination learning? Are both measures required? 4 Rats were trained to discriminate sodium pentobarbital (10mg/kg) vs. saline in two-lever, hunger-motivated operant drug discrimination task. Presses on lever 1 were reinforced when rat was drugged and presses on lever 2 when not drugged (saline). Three types of schedule of reinforcement (FR10, FR30, FR5) were used and the results of them were compared. The phases of drug discrimination learning were shown in Fig.1 to Fig.3. In general, the discrimination learning were rapidly completed despite of differences of schedule. Validity of learning criterion was discussed based upon the results shown in Fig.4 and Fig.5.
横浜国立大学の論文
1984-10-30