Albumin Permeability across Endothelial Monolayers under Long-Term Shear Stress(<Special Issue>Bioengineering)
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概要
- 論文の詳細を見る
Endothelial cells lining the inner surface of blood vessels regulate the exchange of molecules between the blood and the vessel wall. This study investigates the effect of longterm shear stress on macromolecule permeability across endothelial monolayers. In vitro system to measure transendothelial permeability to tetramethylrhodamine conjugated albumin under shear stress was developed. The temporal variation in albumin permeability under 1 Pa and 4 Pa over 48 h was quantified using a fluorescence spectrophotometer. At 4 Pa, albumin permeability did not show a statistical significant change over 48 h. Under shear stress of 1 Pa, the average albumin permeability between 12 and 30h was 2.5-fold higher than the average between 0 and 6h. Under shear stress of 1 Pa, the average albumin permeability between 36 and 48h was 1.8-fold higher than the average between 12 and 30h. These results show that both the magnitude of, and the length of exposure to, shear stress regulate transendothelial permeability.
- 一般社団法人日本機械学会の論文
- 2005-12-15
著者
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池田 雅夫
大阪大学大学院工学研究科
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Ikeda Mariko
School Of Fundamental Sci. And Technol. Keio Univ.
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Ikeda Mariko
芝浦工業大学
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工藤 奨
芝浦工業大学
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Kudo Seishi
Toin Univ. Of Yokohama
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Ikeda Mariko
Department Of System Design Engineering Keio University
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Ikeda Mariko
Keio Leading-edge Laboratory Of Science And Technology Keio University
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Tanishita Kazuo
Department of System Design Engineering Keio University
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KUDO Susumu
Department of Mechanical Engineering, Shibaura Institute of Technology
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TSUZAKA Masanori
Department of System Design Engineering, Keio University
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Kudo Susumu
Department Of Mechanical Engineering Shibaura Institute Of Technology
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Tanishita Kazuo
Department Of System Design Engineering Keio Univ.
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Tanishita Kazuo
Department Of System Engineering
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Tanishita Kazuo
Department Of System Design Engineering
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Tsuzaka Masanori
Department Of System Design Engineering Keio University
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Kudo Susumu
Department of Engineering, Shibaura Institute of Technology
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