The Development of Unusual B Cell Functions in the Testosterone-propionate-Treated Chicken

概要

論文の詳細を見る
Chickens injected with 4mg of testosterone-propionate on the 12th day of egg incubation exhibited unusual B cell functions when immunized; they produced almost exclusively IgM antibodies to sheep red blood cells and influenza virus in the absence of IgG antibody responses and of responses to Brucella abortus and Salmonella pullorum. Bursal remnants were very small in size and had extremely few or no bursal follicles. The bursal lymphoid tissue was replaced substantially by fibrosis. Experiments of adoptive immunization by spleen cells from chickens treated with testosterone-propionate with the supplement of T cells suggested strongly that such unusual immune responses were characteristic of B cell functions of the testosterone-treated chickens but not due to the thymus damage. The adoptive IgM antibody response to sheep red blood cells by spleen cells from the chickens treated with testosterone-propionate was higher than that by spleen cells from untreated control chickens. The unusual B cell functions exhibited by the testosterone-treated chickens were interpreted as functions of the distinct B cell subpopulation possessing the capacity of immune responses restricted to IgM type.
大阪府立大学の論文
1979-03-31