The B Cell Development Independent of the Bursa of Fabricius but Dependent upon the Thymus in Chickens Treated with Testosterone-propionate
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概要
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Most chickens treated with testosterone-propionate on the 12th day of egg incubation (TP12 chickens) and immunized with a mixture of sheep red blood cells, Brucella abortus and Salmonella pullorum produced exclusively IgM antibodies against Sheep red blood cells without the production of IgG antibodies against sheep red blood cells and of antibodies against the bacterial antigens. The development of the bursa in the TP12 chickens was suppressed extremely, and the bursae hardly possessed follicle structures. Spleen cells taken from chickens treated with testosterone-propionate, surgically bursectomized and immunized were treated with anti-bursa cell antiserum in the presence of complement, and toghther with the mixed antigens were transferred into immunodeficient recipient chickens. The recipient chickens restored the capacity to elicit the production of antibodies against sheep red blood cells. In contrast, adoptive immune responses by spleen cells from normal chickens were obliterated by treating the cells with anti-bursa cell antiserum in the presence of complement. The TP12 chickens were thymectomized at 7 days of age (TP12-ST7 chickens) and were immunized with the mixed antigens. The chickens thus treated were totally immunoincompetent. Thymocytes and thymus derived cells taken from normal chickens were introduced into the TP12-ST7 chickens, but the chickens remained totally immunoincompetent. Spleen cells taken from the TP12-ST7 chickens together with spleen cells, containing T cells but not B cells, from normal chickens and with the mixed antigens were injected into immunodeficient recipient chickens. The recipient chickens did not produce antibodies at all indicating the absence of immunocompetent B cells in the spleen of the TP12-ST7 chicken. These findings are discussed in relation to an unusual type of the B cell development in the chicken treated with testosterone-propionate.
- 大阪府立大学の論文
- 1979-03-31
著者
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Hirota Yoshikazu
Laboratory Of Aminal Microbiology College Of Agriculture
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Bito Yukio
Laboratory Of Aminal Microbiology College Of Agriculture
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