口腔扁平上皮癌の原発巣および転移リンパ節におけるリンパ球反応

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The purpose of this study was to gain the information about the lymphocytes reaction in the primary tumor region and metastatic regionallymphnodes. The biopsied specimens and cervicallymphnodes of 8 patients with squamous cell carcinoma in oral cavity who developed cervical metastases were examined. The H-E stained specimens which were biopsied at the initial visiting showed low malignancy points of tumor cell population and high malignancy points of host relationship. The subsets of the lymphocytes infiltrated in the metastatic lymphnodes which were extripated by radical neck dissection were analyzed by the method of Biotin-Avidin-Horseradish Peroxidase using monoclonal antibodies (Leuseries). The most of lymphocytes infiltrated at the marginal part of the metastatic cancer nets were T-cells which were identified with Leu 1 antibody. The subsets of the lymphocytes were suppressor/cytotoxic lymphocytes identified with Leu 2a and helper/inducer lymphocytes identified with Leu 3a+3b. The Leu 3a+3b^+ cells were predominant than the Leu 2a+ cells. The B-cells identified with Leu 14 were almost absent or negligible in the marginal area of the tumor nest and were observed sparsely in the subcortical part. In the primary region, the lymphocytes aggregated around the tumor nests showed similar manner of those in the metastatic lymphnodes. These results suggested that That T-lymphocytes mainly assumed the responsibility of the host-immune defence in both primary region and regional lymphnodes.
神戸大学の論文

口腔扁平上皮癌の原発巣および転移リンパ節におけるリンパ球反応

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