アドレナリン作働性α,β刺激剤の鼻アレルギ-鼻粘膜に対する影響および鼻誘発反応抑制効果に関する研究
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The purpose of our present study was to investigate the direct actions of α- and β-stimulants on the nasal mucosa and their protective effects on allergen-induced nasal symptoms.The preparations under investigation were isoproterenol as a β-stimulant and phenylephrin as an α-adrenostimulant. The dosages of isoproterenol were 0.09 and 0.18mg and for phenylephrine 2.25mg to each nasal cavity. Nasal provocation was performed using the disk method, after administering the drugs or isotonic saline solution as control. Combined rhinomanometry was used for objective evaluation of nasal obstruction. Nasal airway resistance was measured before and after application of the drugs or saline solution, and 10min. after provocation. The number of sneezes was recorded, and serection and swelling of the turbinate were observed by rhinoscopy for 5min. after provocation. Isoproterenol itself did not increase nasal airway resistance, and there was no significant difference between the application of isoproterenol and that of saline.The increase in nasal airway resistance caused by provocation was inhibited after spraying isoproterenol. A dose of 0.19mg of isoproterenol completely inhibited the increase in nasal airway resistance and the allergen-induced nasal symptoms.Phenylephrine itself produced 50% decrease in the nasal airway resistance. Following challenges with allergen, the nasal airway resistance decrease produced with phenylephrine returned to the baseline. Phenylephrine did not inhibit the allergen-induced nasal symptoms.These results have suggested that the function of the α-adrenoceptor on the blood vessels and the β-adrenoceptor on the mast cells or basophils are normal.We consider that topical use of an adequate dose of β-adrenostimulant does not dilate blood vessels and has a mast-cell stabilizing effect in the nose, whereas α-adrenostimulant regulates disturbed nasal blood flow only.
- 耳鼻咽喉科臨床学会の論文
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