Endothelin-1-induced depolarization and hyperpolarization in submandibular ganglion neurons
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概要
- 論文の詳細を見る
The effects of endothelin-1 were studied in vitro on neurons in the hamster submandibular ganglion, using the intracellular microelectrode technique. Endothelin (1μM) caused a depolarization (5.5±1.2mV) followed by a hyperpolarization (8.5±2.8mV) of the membrane potential. Membrane conductance was increased during the endothelininduced depolarization and was decreased during the endothelin-induced hyperpolarization. The endothelin-induced depolarization was depressed (mean 43.6%) in a Krebs solution containing zero calcium and high magnesium. The results suggested that the predominant component of the depolarization was mediated by calcium ions. The calciuminsensitive component of depolarization was carried by chloride ions. Endothelin-induced slow rhythmic hyperpolarizations were probably induced by a decrease in chloride ion conductance.
- 東京歯科大学の論文
著者
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Nakajima T
Department Of Agricultural Chemistry Fuculty Of Agriculture Tohoku University
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Suzuki Takashi
Department Of Physiology Tokyo Dental College
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Suzuki Takashi
Department Of Anesthesia Showa University Northern Yokohama Hospital
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