Dissociation between Pulmonary Capillaries and Alveoli in Congenital Diaphragmatic Hernia Complicated with Persistent Pulmonary Hypertension and Pulmonary Hypoplasia

概要

論文の詳細を見る
Persistent pulmonary hypertension (PPH) is one of the major causes of death in patients with severe congenital diaphragmatic hernia (CDH). Thickening of small muscularized vessels and ventilation-per fusion mismatch have been suggested to be important factors in the development of PPH. The purpose of this study is to characterize the structural alterations of non-muscularized vessels (capillary plexus) and their relations to the respiratory parenchyma in gas exchange zones in CDH patients complicated with PPH and pulmonary hypoplasia. Thirteen patients and twelve controls without significant difference for gestational age and body weight from the patients were studied. Radial alveolar count indices and capillary count indices were compared between cases and controls. Histologically, the disease group showed uneven piling up of capillary plexus loosing single layer configulation in alveolar septa. Histometrical examination revealed marked increase in density of alveolar capillaries in the patients compared with the controls (p<0.0001), in contrast to decreased radial alveolar count indices (p<0.0001). The present study showed that dissociation of alveolar capillary / luminar development have an important role in etiology of PPH which is major fatal complication of CDH.
北里大学の論文
2002-08-31