ずりの負荷が間欠なときの溶血抑制効果 : AFMを用いたせん断力測定(OS.13 溶液・分散系のマイクロ・ナノ構造と流れの相互作用)

概要

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The initial hemolysis rate in a pump circuit is very slow compared with hemolysis in a viscometric flow. This difference in the hemolysis rate is speculated to depend on whether the shear load is continuous or intermittent. In order to verify this speculation, we investigated the mechanical damage of red blood cells in a cone and a plate rheoscope. For RBCs, we loaded continuous or intermittent shear. The intermittent shear was achieved by repeating start and stop of shear alternately. The mechanical damage was compared between the continuous and the intermittent shear test. In the case of the intermittent shear load, the number of the damaged RBC was remarkably suppressed. On the other hand, in the case of continuous shear load, the number of the damaged RBC increased with the shear loading time. This difference suggests that the stop of shear causes recovery of the damaged membrane and suppresses the hemolysis. This recovery effect would bring about the initial gradual progress in the pump hemolysis test.
社団法人日本機械学会の論文
2004-03-03