334 せん断流中における赤血球損傷の回復効果

概要

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The hemolysis rate for a pump circuit is initially very slow compared with hemolysis for viscometric flow. This difference in the hemolysis rate is speculated to depend on whether the shear load is continuous or discontinuous. In order to discuss this speculation, we investigated the mechanical damage suffered by RBC in a cone and a plate rheoscope. For RBC, we applied continuous or discontinuous shear load. The discontinuous shear load means alternating shear and rest. The mechanical damage is compared for each shear loading method under the same shear loading time. In the case of the discontinuous shear load, the number of the damaged RBC was very few, and independent on the shear loading time. On the other hand, in the case of continuous shear load, the number of the damaged RBC increased with the shear loading time. This difference suggests that the rest of shear causes recovery of the damaged membrane and suppresses the hemolysis rate. This recovery effect would be a cause for the initial gradual progress in hemolysis for a pump circuit.
2002-09-20