Triazine系化合物の薬理学的研究(第3報)2-(Benzylidenehydrazino)-4-tert-butyl-6-piperazino-8-triazine(TR-35)の鎮痛抗炎症作用

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Analgesic and anti-inflammatory actions of TR-35 (2-(benzylidenehydrazino)-4-tert-butyl-6-piperazino-s-triazine) were examined and the results are briefly summarized as follows. Analgesic activity of TR-35 was on the whole more potent than that of aminopyrine and comparable to that of mepyrizole in various methods of pain responses such as pressure pain on the mouse tail, electrical stimulation method in mice, and Randall-Selitto's method in rats. TR-35 expressed significant inhibitory effect in the acute edema tests in the rat hind paw. Depressant activity of carrageenin-induced edema was in the descending order of indomethacin, TR-35,mepyrizole, and aminopyrine. TR-35 also showed more potent inhibitory action than indomethacin in serotonin, dextran, and yeast edema tests. On the other hand, inhibitory action of TR-35 on the cotton-pellet granuloma was very weak compared with that of cortisone. Concering the other pharmacological properties, TR-35 exhibited a moderate muscle relaxant action and significantly potentiated the pentobarbital-induced sleeping time in mice. TR-35 was practically devoid of gastroulcerogenic activities in rats. It may be concluded from these results that pharmacological properties of TR-35 are similar to those of basic anti-inflammatory agents.
公益社団法人日本薬学会の論文
1976-04-25