Triazine系化合物の薬理学的研究(第2報)2-Amino-4-Substituted-6-trifluoromethyl-s-triazine誘導体の向精神作用

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Psychosedative action of seven derivatives of 4-substituted 2-amino-6-trifluoromethyl-s-triazines was examined. Among these, 4-[4-(2-hydroxyethyl)piperazin-1-yl] (X) and 4-(4-methylpiperazin-1-yl) (IX) derivatives showed considerable cataleptogenic, antimethamphetamine, and taming effects in mice, in addition to depression of exploratory behavior in rats. 4-Isopropylamino-(I), 4-cyclohexylamino-(IV), and 2-dimethylamino-4-(4-methylpiperazin-1-yl) (XXXIX) derivatives also depressed the exploratory behavior in rats and antagonized the stimulating action of cocaine and caffeine, but they had a very weak activity in other experiments relevant to psychosedative action. 2-Methylamino-4-isopropylamino derivative (XLIII) only inhibited the stimulating action of cocaine and 4-(p-chloroanilino) derivative (VI) slightly depressed the stimulating action of methamphetamine, cocaine, and caffeine. A slight loss of righting reflex in mice was observed only at the lethal dose of the seven derivatives. Judging from these results, the type of action of X and IX was considered to be similar to that of neuroleptics. It seems that piperazine substituent in the triazines played some role for the manifestation of such pharmacological properties as neuroleptics.
公益社団法人日本薬学会の論文
1976-03-25

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