Triazine系化合物の薬理学的研究(第4報)2-(Benzylidenehydrazino)-4-tert-butyl-6-piperazino-s-triazine(TR-35)の一般薬理作用

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General pharmacological actions of 2-(benzylidenehydrazino)4-tert-butyl-6-piperazino-s-triazine (TR-35) were examined. TR-35 showed a moderate sedative, muscle-relaxant, and anti-convulsant actions in mice and these effects were more potent than those of meprobamate. Basic anti-inflammatory agents such as mepyrizole or diphenamisol also showed these properties, Although TR-35 expressed taming effects in mice and rats, it had no depressant action against conditioned avoidance response and methamphetamine-induced hypermotility. As for autonomic nervous system or smooth muscle, TR-35 seemed to have a weak ganglion blocking and faint smooth muscle directing actions. Little effect was also observed on blood pressure of urethane anaesthetized rat.
公益社団法人日本薬学会の論文
1976-06-25