ヘテロ環化合物の研究(第24報)3,4-ジフェニールフラン誘導体の合成とその抗菌活性についてその2

概要

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Three kinds of novel 3,4-bis(4-substituted phenyl)-2-furaldehydes were obtained by formylation of 3,4-bis (4-substituted phenyl) furans (R=H, OCH_3,CH_3) with phosphorus trichloride in dimethylformamide. Novel methyl 3,4-diphenyl-5-formyl-2-furancarboxylate was synthesized from methyl 5-chloromethyl-3,4-diphenyl-2-furancarboxylate by the Kronke-Borner method. Condensation of 3,4-diphenyl-2-furaldehyde and acetaldehyde resulted in the formation of a novel 3-(3,4-diphenyl-2-furyl) acrolein. 3,4-Diphenyl-2-furaldehyde was submitted to the Cannizzaro, Perkin, Wittig, reduction reactions, and condensation with amines. The corresponding Schiff's bases were obtained by the reaction of 3,4-bis (4-methoxyphenyl)-2-furaldehyde and amines. The Schiff's base-type compounds and vinylene-type compounds thereby obtained were tested for their antibacterial activity and a wide antibacterial spectrum was found in some of the Schiff's base-type compounds of 3,4-bis (4-substituted phenyl)-2-furaldehydes and aminoguanidines.
公益社団法人日本薬学会の論文
1975-02-25