ヘテロ環化合物の研究(第27報)5-ニトロ-3,4-ジフェール-2-フルアルデヒドならびにその誘導体の合成と抗菌性についてその4

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In order to examine whether a nitro group in the furan ring of 3,4-diphenylfuran derivatives is required for their antibacterial activity, 5-nitro-3,4-bis (4-substituted phenyl)-2-furaldehydes (IV and XII) and their derivatives were synthesized, 5-Nitro-3,4-diphenyl-2-furaldehyde (IV) was synthesized from 3,4-diphenyl-2-furaldehyde (I), via 3,4-diphenyl-2-(1,3-dioxolan-2-yl) furan (VII), acetine intermediate, 5-nitro-3,4-diphenyl-2-(1,3-dioxo1an-2-yl)-2-acetoxy-2,5-dihydrofuran (VIII), and 5-nitro-3,4-diphenyl-2-(1,3-dioxolan-2-yl) furan (IX). Similarly, 5-nitro-3,4-bis (4-methoxyphenyl)-2-furaldehyde (XII) was synthesized but its acetine intermediate could not be isolated. Antibacterial tests of these compounds showed them to be practically ineffective.
公益社団法人日本薬学会の論文
1975-10-25