In Vitro Screening of Human and Bovine Placenta Extracts Used as an Active Component in Cosmetics

概要

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We performed in vitro screening of human and bovine placenta extracts (PE) used as an active component in cosmetics. Evaluation of the cell proliferative action and determination of the sialic acid content and alkaline-phosphatase (ALP) activity showed marked differences among PE samples, but no association among the results was observed. The stability of L-ascorbic acid phosphate magnesium salt (VC-PMg) used for whitening in cosmetics was also examined by PE. VC-PMg was hydrolyzed to L-ascorbic acid following the pseudo-first-order reaction by PE showing ALP activity. PE with high ALP activity required only a short time to degrade VC-PMg by 50%. Each PE sample differed in its efficacy as a cosmetic material. Attention should be given paid to its combination with VC-PMg as a whitening agent.
公益社団法人日本薬学会の論文
1996-04-30