Potentiation of Isoproterenol-Stimulated Gluconeogensis in Serum-Free Cultures of Rat Hepatocytes by Nifedipine and Nicardipine
スポンサーリンク
概要
- 論文の詳細を見る
The effects of nifedipine and nicardipine on isoproterenol-stimulated gluconeogenesis from 10mM lactate were examined in serum-free cultures of rat hepatocytes. Nifedipine and nicardipine (10^<-7>-10^<-5>M) significantly potentiated the isoproterenol-stimulated gluconeogenesis from 10mM lactate by increasing intracellular cAMP levels. In contrast, diltiazem and verapamil (10^<-7>-10^<-6>M) did not potentiate it. 1-Methyl-3-isobutylxanthine (IBMX; 10^<-6>-10^<-4>M), which is known to inhibit phosphodiesterase activity, dose-dependently potentiated isoproterenol-stimulated gluconeogenesis from lactate in serum-free cultures of rat hepatocytes. In parallel, IBMX also increased the isoproterenol-induced intracellular concentrations of cAMP in a dose-dependent manner. These results suggest that the possible mechanism by which nifedipine and nicardipine potentiate the isoproterenol-stimulated gluconeogenesis is related to the increase of cAMP levels through the inhibition of cAMP phosphodiesterase.
- 公益社団法人日本薬学会の論文
- 1993-08-15
著者
関連論文
- Poly-L-arginine enhances paracellular permeability via serine/threonine phosphorylation of ZO-1 and tyrosine dephosphorylation of occludin in rabbit nasal epithelium
- 口臭原因物質に対する口臭除去物質の除去効果
- 薬の写真をのせた薬袋による情報提供の有用性評価:写真入り情報提供せんとの比較
- 薬の写真をのせた薬袋による情報提供の有用性評価 : 写真入り情報提供せんとの比較
- Nifedipine and Nicardipine Potentiate Glucagon-Stimulated Glycogenolysis in Primary Cultures of Rat Hepatocytes
- Potentiation of Isoproterenol-Stimulated Gluconeogensis in Serum-Free Cultures of Rat Hepatocytes by Nifedipine and Nicardipine
- 摘出皮膚代替 in vitro 経皮吸収試験法に用いるヒト皮膚類似人工膜の調製とその評価に関する研究
- Glycyrrhizin and some analogues induce growth of primarycultured adult rat hepatocytes via epidermal growth factorreceptors
- Prostaglandin E2 (EP1) receptor agonist-induced DNAsynthesis and proliferation in primary cultures of adult rathepatocytes : The involvement of transforming growth factor-α
- Stimulation of DNA synthesis and proliferation by prostaglandins inprimary cultures of adult rat hepatocytes[
- Stimulation by transforming growth factor-a of DNA synthesisand proliferation of adult rat hepatocytes in primary cultures :Modulation by a- and b-adrenoceptor agonists
- Transforming growth factor-b1 inhibits the growth of primary adult rat hepatocyte cultures by increasing cAMPlevels
- 肝実験細胞の増殖を促進する因子の作用機構
- 紫外線照射によるSwiss 3T3 細胞の傷害及びプロスタグランジンE_2遊離に対する漢方方剤四物湯の抑制作用
- In Vitro Screening of Human and Bovine Placenta Extracts Used as an Active Component in Cosmetics