コリスチン関連化合物の研究(第10報)コリスチン誘導体の合成と抗菌活性について

概要

論文の詳細を見る
In order to obtain better antibiotics than natural colistin, colistin derivatives were synthesized by replacing 6-methyloctanoic acid or 6-methylheptanoic acid in colistin with various organic acids or aromatic sulfonic acids. Twenty kinds of (2-acylamido-or -stlfonamido-4-aminobutyric acid)^<1'>-colistin were obtainee by the condensation of organic acids with pentabenzyloxycarbonyldeacylcolistin^<1)> by the dicyclohexylcarbodiimide method or with acyl chloride or sulfonyl chloride by the Schotten-Baumann reaction, followed by liberation of the benzyloxycarbonyl group. Among these derivatives of colistin, two of them showed antibacterial activity against gram-negative bacteria equal to that of colistin sulfate and two that showed an effect against gram-positive bacteria.
公益社団法人日本薬学会の論文
1974-11-25