アルブミン値低下を伴ったてんかん患者のフェニトイン蛋白結合率の変動

概要

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The plasma protein binding of phenytoin in man is about 90% and the impaired plasma binding may lead to large variations in the unbound fraction of phenytoin in the plasma. In the present study, the percent of unbound phenytoin was accurately determined by equilibrium dialysis by using ^<14>C-labeled phenytoin. When intra- and intersubject differences in the plasma binding were studied in 22 patients during long-term treatment with phenytoin, a strong linear correlation was observed between the unbound fraction of phenytoin, a strong linear correlation was observed between the unbound fraction of phenytoin and albumin concentration. The obtained results of the linear correlation were demonstrated to be of clinical significance in predicting the percentage of unbound phenytoin in patients with moderate hypoalbuminemia (plasma albumin of 2.0 to 3.0 g/100ml).
社団法人日本薬学会の論文
1985-05-25