SIMILAR EFFECTS OF VARIOUS LOW-MOLECULAR-WEIGHT ENZYME INHIBITORS ON ENZYME NETWORKS IN DYSTROPHIC MICE
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概要
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We compared the therapeutic effects of various low-molecular-weight enzyme inhibitors on dystrophic mice. Leupeptin, bestatin, forphenicinol and forphenicine significantly affected the enzymatic activities in the dystrophic muscles. The pattern of enzymatic changes in the muscles of forelimb and hindlimb caused by these inhibitors were similar in spite of the variety of their inhibitory spectra in vitro. However, comparing the pattern of enzymatic changes in spleen, forphenicinol differed from the other inhibitors tested. This may be related to the peculiar effects of this inhibitor on immunologically responsive cells.
- 公益社団法人日本薬学会の論文
著者
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HATTORI Seiko
Institute of Microbial Chemistry
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Hattori S
Microbial Chemistry Research Center
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HARADA Shigeko
Institute of Microbial Chemistry
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KOJIMA Fukiko
Institute of Microbial Chemistry
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AOYAGI Takaaki
Institute of Microbial Chemistry
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UMEZAWA HAMAO
Institute of Microbial Chemistry
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Wada Takao
Institute Of Microbial Chemistry
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Ohuchi Shokichi
Institute Of Microbial Chemistry
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Nagai Machiko
Institute Of Microbial Chemistry
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Aoyagi T
Inst. Microbial Chemistry Tokyo Jpn
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Aoyagi T
Institute Of Microbial Chemistry
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Aoyagi Takaaki
Department Of Hygienic Chemistry Showa College Of Pharmaceutical Sciences
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Nagai Machiko
Intitute Of Microbioal Chemistry M. C. R. F
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Umezawa Hamao
Institute of Bioorganic Chemistry
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