Synthesis of 6′-Amino-1-<I>N</I>-[(<I>S</I>)-4-Amino-2-Hydroxybutyryl]-6′-Deoxylividomycin A
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概要
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The titled compound (<B>11</B>) was prepared from lividomycin A. A partially protected cyclic 1,6-carbamate derivative (<B>6</B>), which has free hydroxyl groups at C-4′ and C-6′, was prepared, and the 6′-hydroxyl group was selectively tosylated. Replacement of the tosyl group by azido group, followed by partial hydrolysis of the carbamate ring gave the aminol (<B>9</B>). Acylation of the free C-1-amino group with (<I>S</I>)-4-amino-2-hydroxybutyric acid and hydrogenation of the azido group led to <B>11</B> Preparation of 4′,6′-di-<I>O</I>-methyllividomycin A (<B>13</B>) was also described.
- 公益社団法人 日本化学会の論文
著者
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Watanabe Isamu
Department Of Pediatrics Johoku Hospital Western Medical Center
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Umezawa Sumio
Department of Applied Chemistry Engineering Faculty Keio University
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Tsuchiya Tsutomu
Department of Applied Chemistry, Faculty of Engineering, Keio University
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Umezawa Hamao
Institute of Bioorganic Chemistry
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Ejima Akio
Department of Applied Chemistry, Faculty of Engineering, Keio University
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