An improved synthesis of 3',4'-dideoxykanamycin B.
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概要
- 論文の詳細を見る
A new synthetic route has been exploited for the large scale production of 3′,4′-dideoxykanamycin B starting with kanamycin B. The key stage in the synthesis involves the formation in excellent yield of the 3′,4′-anhydro-4′-<I>epi</I> derivative (<B>5</B>) followed by convertion to the 3′-<I>ene</I> derivative through the iodohydrin. Compound <B>5</B> was prepared by the treatment of 3′,2″-di-<I>O</I>-benzoyl-4″,6″-<I>O</I>-cyclohexylidene-4′-<I>O</I>-methylsulfonyl-penta-<I>N</I>-<I>t</I>-butoxycarbonyl-kanamycin B with sodium methoxide.
- 公益社団法人 日本化学会の論文
著者
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Umezawa Hamao
Institute of Bioorganic Chemistry
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Yoneta Toshio
Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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Shibahara Seiji
Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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Seki Shigeo
Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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Yoneta Toshio
Central Research Laboratories, Meiji Seika Co., Ltd.
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Matsuno Tomio
Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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Tohma Susumu
Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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Fukatsu Shuzo
Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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