A new synthesis of L-4-amino-2-hydroxybutyric acid. Carboxyl-assisted nitrile synthesis from primary amides.

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概要

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• L-2-Hydroxysuccinamic acid prepared from L-asparagine was dehydrated with acetic anhydride in pyridine, affording the respective ω-cyano acid, which, on catalytic hydrogenation, gave the title compound. Similarly, the amide groups of some other β- and γ-amic acids were dehydrated to give the respective cyano acids in good yields.

• 公益社団法人 日本化学会の論文

著者

• Fukatsu Shunzo

  Central Research Laboratories, Meiji Seika Co., Ltd.

• Fukatsu Shunzo

  Central Research Laboratories, Meiji Seika Kaisha, Ltd.

• Yoneta Toshio

  Central Research Laboratories, Meiji Seika Kaisha, Ltd.

• Shibahara Seiji

  Central Research Laboratories, Meiji Seika Kaisha, Ltd.

• Seki Shigeo

  Central Research Laboratories, Meiji Seika Kaisha, Ltd.

• Yoneta Toshio

  Central Research Laboratories, Meiji Seika Co., Ltd.

関連論文

• Syntheses of 1-epikanamycin A and its 1-N-((S)-4-amino-2-hydroxybutyryl) derivative.
• A new synthesis of L-4-amino-2-hydroxybutyric acid. Carboxyl-assisted nitrile synthesis from primary amides.
• Syntheses of 2',3'-dideoxykanamycin A, 2',3'-dideoxyamikacin and related substances.
• An improved synthesis of 3',4'-dideoxykanamycin B.

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