DIFFERENCE IN ENZYME NETWORKS BETWEEN MOUSE AND HAMSTER MODELS OF MUSCULAR DYSTROPHY
スポンサーリンク
概要
- 論文の詳細を見る
The present study was undertaken to compare the peculiarity of enzymatic changes in dystrophic hamsters and mice. Various enzymatic activities in muscle, bone, heart, spleen, liver and kidney were measured. The enzymes tested include 7 aminopeptidases, 5 endopeptidases, 3 glycosidases, creatine kinase, phosphatase and esterase. In dystrophic mice, the enzymatic changes were chiefly confined to muscle and bone. In dystrophic hamsters, on the other hand, extensive and pronounced changes in enzymatic activities were seen not only in skeletal muscle but also in bone, heart muscle, spleen, liver and kidney. Furthermore, resemblance of pattern of enzymatic changes was seen among several organs including skeletal muscle, heart muscle, bone and spleen in the hamster model. Comparing the enzymatic changes in these two models, dystrophic mouse may be regarded as more specific a model for musculoskeletal diseases. Dystrophic hamster may be related more to multiorgan diseases possibly associated with immunological or other systemic diseases. These models may represent two different disease categories, respectively.
- 公益社団法人日本薬学会の論文
著者
-
KOJIMA Fukiko
Institute of Microbial Chemistry
-
AOYAGI Takaaki
Institute of Microbial Chemistry
-
UMEZAWA HAMAO
Institute of Microbial Chemistry
-
Wada Takao
Institute Of Microbial Chemistry
-
Nagai Machiko
Institute Of Microbial Chemistry
-
Aoyagi T
Inst. Microbial Chemistry Tokyo Jpn
-
YAMAMOTO KAZUMORI
Institute of Microbial Chemistry
-
Aoyagi T
Institute Of Microbial Chemistry
-
Aoyagi Takaaki
Department Of Hygienic Chemistry Showa College Of Pharmaceutical Sciences
-
Nagai Machiko
Intitute Of Microbioal Chemistry M. C. R. F
-
Umezawa Hamao
Institute of Bioorganic Chemistry
関連論文
- Sulphostin, a Potent Inhibitor for Dipeptidyl Peptidase IV from Streptomyces sp. MK251-43F3
- Biosynthesis of Neothramycin
- Microbial Serine Carboxypeptidase Inhibitors : Comparative Analysis of Actions on Homologous Enzymes Derived from Man, Yeast and Wheat
- PB130 SIASTATIN B, A POTENT SIALIDASE INHIBITOR : THE TOTAL SYNTHESIS, ABSOLUTE CONFIGURATION AND BIOLOGICAL ACTIVITY
- ENZYMATIC CHANGES IN VARIOUS ORGANS OF GUINEA PIGS CAUSED BY THE ADMINISTRATION OF FREUND'S COMPLETE ADJUVANT
- SYSTEMIC ENZYMATIC CHANGES IN GUINEA PIGS SUFFERING FROM EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
- Synthesis of 4'-O-Acylanthracyclines(Organic Chemistry)
- Fluostatins A and B, New Inhibitors of Dipeptidyl Pehtidase III, Produced by Streptomyces sp. TA-3391 II. Structure Determination
- Poststatin, a New Inhibitor of Prolyl Endopeptidase VIII. Endopeptidase Inhibitory Activity of Non-peptidyl Poststatin Analogues
- Poststatin, a New Inhibitor of Prolyl Endopeptidase VII. N-Cycloalklamide Analogues
- Poststatin, a New Inhibitor of Prolyl Endopeptidase VI. Endopeptidase Inhibitory Activity of Poststatin Analogues Containing Pyrrolidine Ring
- Poststatin, a New Inhibitor of Prolyl Endopeptidase V. Endopeptidase Inhibitory Activity of Poststatin Analogues
- Poststatin, a New Inhibitor of Prolyl Endopeptidase IV. The Chemical Synthesis of Poststatin
- Poststatin, a New Inhibitor of Prolyl Endopeptidase III. Optical Resolution of 3-Amino-2hydroxyvaleric Acid and Absolute Configuration of Postsatin
- Fluostatins A and B, New Inhibitors of Dipeptidyl Peptidase III, Produced by Streptomyces sp. TA-3391 I. Taxonomy of Producing Strain, Production, Isoloation, Physico-chemical Properties and Biological Properties
- Induction of Apoptosis and Cell Cycle Arrest in Mouse Colon 26 Cells by Benastatin A
- A Facile Synthesis of D-Galctose-type Gem-Diamine 1-N-Iminosugar: A New Family of Galactosidase Inhibitor
- Epostatin, New Inhibitor of Dipeptidyl Peptidase II, Produced by Streptomyces sp. MJ995-OF5 I. Taxonomy of Producing Strain, Fermentation, Isolation, Physico-chemical Properties and Biological Properties
- Phebestin, a New Inhibitor of Aminopeptidase N, Produced by Streptomyces sp. MJ716-m3
- SIMILAR EFFECTS OF VARIOUS LOW-MOLECULAR-WEIGHT ENZYME INHIBITORS ON ENZYME NETWORKS IN DYSTROPHIC MICE
- DIFFERENCE IN ENZYME NETWORKS BETWEEN MOUSE AND HAMSTER MODELS OF MUSCULAR DYSTROPHY
- RELATION BETWEEN IN VIVO EFFECTS AND IN VITRO EFFECTS OF SERINE AND THIOL PROTEINASE INHIBITORS
- INTRAMUSCULAR ENZYME ABNORMALITIES OF DYSTROPHIC CHICKENS COMPARED TO THOSE OF DYSTROPHIC MICE
- New Anthracycline Antibiotic CG12 Obtained by Microbial Glycosidation of α-Citromycinone
- Epostatin, New Inhibitor of Dipeptidyl Peptidase II, Produced by Streptomyces sp. MJ995-OF5 II. Structure Elucidation
- IMMUNOLOGICAL CROSS-REACTIVITIES OF VARIOUS ANTHRACYCLINE ANTIBIOTICS AGAINST ACLACINOMYCIN A ANTISERA
- NOREPINEPHRINE-SYNTHESIZING ENZYMES IN BRAIN, ADRENALS AND PERIPHERAL SYMPATHETIC NERVES OF SPONTANEOUSLY HYPERTENSIVE RATS
- IRON COMPLEXES OF BLEOMYCIN AND DEGLYCO-BLEOMYCIN : SPECTROSCOPIC PROPERTIES AND NUCLEOTIDE SEQUENCE SPECIFICITY IN DNA CLEAVAGES
- THE ROLE OF ENZYME INHIBITORS IN THE BIOLOGICAL CONTROL
- Decalpenic acid, a novel small molecule from Penicillium verruculosum CR37010, induces early osteoblastic markers in pluripotent mesenchymal cells
- Total synthesis of minosaminomycin.
- Synthesis of (14R)- and (14S)-14-de(hydroxymethyl)-14-hydroxymycaminosyl tylonolides.
- Prophylactic and therapeutic effect of bactobolin on autoimmune encephalomyelitis.
- Synthesis and Structure-activity Relationships of Amastatin Analogues, Inhibitors of Aminopeptidase A
- Transformation of dihydrostreptomycin into 3"-deoxydihydrostreptomycin.
- Studies on Aminosugars. XXXVI. Syntheses of 3′,4′-Dideoxy-and 3′,4′,5″-Trideoxyribostamycin
- The Improvement of Productivity and Selective Production of Arphamenines by Addition of Their Biosynthetic Precursors
- Synthesis of 6′-Amino-1-N-[(S)-4-Amino-2-Hydroxybutyryl]-6′-Deoxylividomycin A
- Studies on Aminosugars. XXXV. Syntheses of 3′,4′-Dideoxyneamine and 3′- and 4′-O-Methylneamines
- Total syntheses of indicine N-oxide, intermedine N-oxide, and their enantiomers using carbohydrate as a chiral educt.
- Studies of the effect of spermidine in enhancing cellular immunity.
- Studies on lignan lactone antitumor agents. IV. Synthesis of glycosidic lignan variants related to .ALPHA.-peltatin.
- Synthesis of Butirosin B and Its 3′,4′-Dideoxy Derivative
- Studies on Aminosugars. XXX. The Synthesis of 3′-Deoxykanamycin
- Syntheses of 1-epikanamycin A and its 1-N-((S)-4-amino-2-hydroxybutyryl) derivative.
- Syntheses of 2',3'-dideoxykanamycin A, 2',3'-dideoxyamikacin and related substances.
- An improved synthesis of 3',4'-dideoxykanamycin B.
- Synthesis of 5"-deoxy-5"-fluorolividomycin B.
- Synthesis of a masked derivative of 3'-deoxydihydrostreptobiosamine, a precursor for the synthesis of 3"-deoxydihydrostreptomycin.
- Synthesis of a lividomycin B analogue, 5-O-[3-O-(2-amino-2-deoxy-.ALPHA.-D-glucopyranosyl)-.BETA.-D-ribofuranosyl]-3'-deoxyparomamine.
- Human skeletal muscle contains two major aminopeptidases: An anion-activated aminopeptidase B and an aminopeptidase M-like enzyme.