SYSTEMIC ENZYMATIC CHANGES IN GUINEA PIGS SUFFERING FROM EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS

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概要

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• Experimental allergic encephalomyelitis (EAE) is one of the experimental models of human demyelinating diseases and recently is regarded also as useful model for studying cell-mediated autoimmune diseases. Because of the possibility of induction of systemic changes in this model, we investigated enzymatic changes in serum and main organs of the diseased animals, including brain, spinal cord, limb muscle, heart muscle, spleen, liver and kidney. The enzymes measured consisted of 7 aminopeptidases, 5 endopeptidases, 3 glycosidases, creating kinase, phosphatase and esterase. Significant changes of many enzymatic activities occurred in all the organs tested in 1 to 2 weeks after the administration of EAE antigen, myelin basic protein (MBP). Interesting correlations of the pattern of enzymatic changes were seen among most of the organs tested. Those patterns changed in the course of the 2 weeks and there remanied marked changes characteristic for each organ. This model may represent some type of systemic autoimmune diseases.

• 公益社団法人日本薬学会の論文

著者

• KOJIMA Fukiko

  Institute of Microbial Chemistry

• AOYAGI Takaaki

  Institute of Microbial Chemistry

• UMEZAWA HAMAO

  Institute of Microbial Chemistry

• Wada Takao

  Institute Of Microbial Chemistry

• Nagai Yoshitaka

  Department Of Biochemistry Faculty Of Medicine University Of Tokyo

• NAGAI MACHIKO

  Department of Enzymology, Institute of Microbial Chemistry

• UMEZAWA HAMAO

  Department of Enzymology, Institute of Microbial Chemistry

• Nagai Machiko

  Institute Of Microbial Chemistry

• Aoyagi T

  Inst. Microbial Chemistry Tokyo Jpn

• Aoyagi T

  Institute Of Microbial Chemistry

• Aoyagi Takaaki

  Department Of Hygienic Chemistry Showa College Of Pharmaceutical Sciences

• Nagai Machiko

  Intitute Of Microbioal Chemistry M. C. R. F

• Nagai Yoshitaka

  Department Of Biochemical Cell Research The Tokyo Metropolitan Institute Of Medical Science

• UMEZAWA Hamao

  Department of Biochemistry, School of Dentisty, Aichi-Gakuin University

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