Synthesis of Bridged Steroids. III. Cholestane Derivatives having a Bridged Bicyclo [2. 2. 2] octane Ring System of the Atisine Type
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概要
- 論文の詳細を見る
Synthesis of the cholestane derivative (V) having a bridged bicyclo [2. 2. 2] octane ring system of the atisine type was attained by various routes starting from 5α-cyanocholestan-3-one (II) as illustrated in Chart 4. The route through the ketal aldehyde (X) and 5α-vinylcholestan-3-one 3-ethylene ketal (XV), the key intermediate for the present synthesis, was found to be most advantageous. However, another route through the bridged acetoxy mesylate (XVI) is also thought to be important, since this intermediate is commonly used for the synthesis of the kaurene-type bridged ring compounds as decribed in the preceding paper. The allylic alcohol function of the atisine type was introduced at the corresponding position with opposite configuration of the hydroxy group giving compound (XXXVIII).
- 社団法人日本薬学会の論文
- 1968-05-25
著者
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菅沢 勉
Shionogi Research Laboratories, Shionogi & Co., Ltd.
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永田 亘
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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成定 昌幸
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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永田 亘
塩野義製薬株式会社研究所
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永田 亘
Shionogi Research Laboratories Shionogi & Co. Ltd.
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成定 昌幸
塩野義製薬株式会社研究所
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若林 利生
Shionogi Research Laboratory
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菅沢 勉
Shionogi Research Laboratories Shionogi & Co. Ltd.
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若林 利生
Shionogi Research Laboratory:(present Address)central Research Institute Teijin Limited
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