Experiments on the Synthesis of dl-Camptothecin. III. Total Synthesis of dl-Camptothecin
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概要
- 論文の詳細を見る
dl-Camptothecin (XXX) and two epimeric N-formyl-1,2,6,7-tetrahydrocamptothecins (XXIIIa, b) have been synthesized from 3-oxo-1H-pyrrolo [3,4-b] quinoline IIIa by using following two key reactions. 1) An intramolecular aldol condensation of the imido-ester (VIIIb→IXb). 2) Vilsmeier reaction on a 4-methoxy-2-pyridone ring (XVIb→XVII) followed by nucleophilic attack of a malonate carbanion onto the formyl-pyridone ring (XVII→XVIII).
- 社団法人日本薬学会の論文
- 1974-04-25
著者
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笹倉 和幸
Shionogi Research Laboratories, Shionogi & Co., Ltd.
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菅沢 勉
Shionogi Research Laboratories, Shionogi & Co., Ltd.
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笹倉 和幸
Shionogi Research Laboratories Shionogi & Co. Ltd.
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豊田 達郎
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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菅沢 勉
Shionogi Research Laboratories Shionogi & Co. Ltd.
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豊田 達郎
Shionogi Research Laboratory Shionogi & Co. Ltd.
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