Synthesis of Bridged Steroids. V. Cholestane Derivatives having a Bridged 3-Azabicyclo [3. 3. 1] nonane Ring System
スポンサーリンク
概要
- 論文の詳細を見る
Cholestane derivative (IIb) having a bridged 3-azabicyclo [3. 3. 1] nonane ring system was synthesized from 3-oxo-5α-cholestane-5-carbonitrile (III) by a six-step reaction sequence. The over-all yield was very high indicating high stereospecificity or uniformity of the reaction used. Reduction of 3α-formyl-3β-methyl-5α-cholestane-5-carbonitrile (VIII) to the amino alcohol (Xa) was effected by means of lithium aluminum hydride reduction in the presence of aluminum chloride.
- 公益社団法人日本薬学会の論文
- 1968-08-25
著者
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永田 亘
Shionogi Research Laboratories Shionogi & Co. Ltd.
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青木 務
塩野義研
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菅沢 勉
Shionogi Research Laboratories Shionogi & Co. Ltd.
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青木 務
Shionogi Research Laboratory Shionogi & Co., Ltd.
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