40 dl-Camptothecinの全合成

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概要

• 論文の詳細を見る

• The D,E-ring system of dl-camptothecin (+ Camptothecin is an alkaloid with a novel ring system exhibiting potent antileukemic and antitumor activity) was synthesized by application of Vilsmeier reaction to a model compound III, followed by addition of malonester (Chart I). This D,E-ring formation was not successful with XV, but the tetrahydro derivative XVIII could undergo the ring formation to give lactone XXI, which was converted to dl-camptothecin. The 4-methoxy-2-pyridone ring moiety of XV was obtained by a unique intramolecular aldol-type condensation (Chart II).

• 天然有機化合物討論会の論文
• 1972-10-01

著者

• 笹倉 和幸

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• 菅沢 勉

  塩野義製薬研究所

• 豊田 達郎

  塩野義製薬研究所

• 笹倉 和幸

  塩野義製薬研究所

• 菅沢 勉

  Shionogi Research Laboratories Shionogi & Co. Ltd.

• 豊田 達郎

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 菅沢 勉

  塩野義製薬 (株) 研究所

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• Experiments on the Synthesis of dl-Camptothecin. III. Total Synthesis of dl-Camptothecin
• Experiments on the Synthesis of dl-Camptothecin. II. Synthesis of a D-E Ring Analog of Camptothecin and a Total Synthesis of Ricinine
• Experiments on the Synthesis of dl-Camptothecin. I. Attempted Synthesis of Potential Ring A-B-C Components
• 40 dl-Camptothecinの全合成
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