Studies on Antiviral Agents. III. Synthesis of Tenuazonic Acid Derivatives.
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概要
- 論文の詳細を見る
Tenuazonic acid derivatives were synthesized from amino acid esters by N-acetoacetylation with diketene followed by cyclization with sodium alkoxides. Some L-amino acid produced a small amount of DL-compounds in this process. N-Acetoacetyl group of diethyl aspartate cyclized to the α-ester group to form five-membered ring compound selectively. These compounds were condensed with carbonyl reagents.
- 公益社団法人日本薬学会の論文
- 1967-08-25
著者
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東平 靖雄
Research Laboratories Chugai Pharmaceutical Co. Ltd.
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高間 伸一
Research Laboratory, Chugai Pharmaceutical Co., Ltd.
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由岐 英剛
Department of Clinical Chemistry, School of Pharmaceutical Science, Toho University
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由岐 英剛
Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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高間 伸一
Research Laboratories Chugai Pharmaceutical Co. Ltd.
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青木 文彌
Research Laboratories Chugai Pharmaceutical Co. Ltd.
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由岐 英剛
Faculty Of Pharmaceutical Sciences Osaka University
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由岐 英剛
Department Of Clinical Chemistry School Of Pharmaceutical Science Toho University
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加納 外記雄
Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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山崎 強志
Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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山崎 強志
Research Laboratories Chugai Pharmaceutical Co. Ltd.
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加納 外記雄
Research Laboratories Chugai Pharmaceutical Co. Ltd.
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