Rapid Effect of Interferon-γ on Human Monocyte Chemiluminescence
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概要
- 論文の詳細を見る
The effect of lymphokines and interferon-γ on human monocyte chemiluminescence was studied by measuring the phorbol myristate acetate-induced luminol-dependent chemiluminescence. When human peripheral blood monocytes were incubated with lymphokines (culture supernatants of concanavalin A-stimulated human leukocytes), their ability to generate chemiluminescence increased rapidly, reaching a maximal level at about 4 h, and then decreased on further incubation. Similar results were obtained in experiments using a commercially available human interferon-γ in place of crude lymphokines. The increasing effect of interferon-γ on monocyte chemiluminescence was dose-dependent in the range of 0.1-10^2 U/ml. These results show that the monocyte chemiluminescence may be clinically useful as a simple and rapid method for the determination of human interferon-γ.
- 公益社団法人日本薬学会の論文
- 1988-05-25
著者
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武藤 里志
Department Of Clinical Chemistry School Of Pharmaceutical Science Toho University
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峯村 博道
Department of Clinical Chemistry, School of Pharmaceutical Science, Toho University
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由岐 英剛
Department of Clinical Chemistry, School of Pharmaceutical Science, Toho University
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峯村 博道
Department Of Clinical Chemistry School Of Pharmaceutical Science Toho University
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由岐 英剛
Faculty Of Pharmaceutical Sciences Osaka University
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由岐 英剛
Department Of Clinical Chemistry School Of Pharmaceutical Science Toho University
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