The Synthesis of 8-Substituted Purine Derivatives. II. Some 8-Substituted 6-Mercaptopurines.
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概要
- 論文の詳細を見る
Some 6-mercaptopurine derivatives substituted at 8-position with hydrophilic groups such as -SH, -S-CH_2-COOH, -CH_2-CH_2-COOH, -CH_2OH, -COOH, and -NH-CH_3 were synthesized for testing purine-antagonist action. They were prepared by the condensation of 4,5-diamino-6-mercaptopyrimidine (I) with thiourea, succinic acid, glycolic acid, or ethyl oxalate, except in the case of 6-mercapto-8-methylaminopurine. In the condensation of (I) with oxalic acid, 7-aminothiazolo [5,4-d] pyrimidine was directly obtained in considerable amount under alternative ring closure.
- 公益社団法人日本薬学会の論文
著者
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石館 守三
Pharmaceutical Institute, Medical Faculty, University of Tokyo
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石館 守三
Pharmaceutical Institute Medical Faculty University Of Tokyo
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由岐 英剛
Faculty Of Pharmaceutical Sciences Osaka University
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由岐 英剛
Department Of Clinical Chemistry School Of Pharmaceutical Science Toho University
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由岐 英剛
Pharmaceutical Institute, Medical Faculty, University of Tokyo
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由岐 英剛
Pharmaceutical Institute Medical Faculty University Of Tokyo
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