Studies on Antiviral Agents. I. Relationship between Chemical Reactivity of Sulfhydryl Reagents and Their Inactivating Activity of Adenovirus Type 5
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概要
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Seventy-one possible sulfhydryl reagents were examined on the chemical reactivity with methyl N-acetylcysteinate, as well as on the inactivating ability against adenovirus type 5. It has been found that the compounds capable of inactivating the virus are always accompanied by the chemical reactivity with the SH group of methyl N-acetylcysteinate, and that the compounds incapable of reacting with the SH group are unable to exhibit the virus-inactivating activity either. Above all, the compounds, whose chlorine atom is directly linked to a nitrogen atom, have shown a marked virus inactivating activity.
- 公益社団法人日本薬学会の論文
- 1966-02-25
著者
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高間 伸一
Research Laboratory, Chugai Pharmaceutical Co., Ltd.
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佐野 文彦
Research Laboratories Chugai Pharmaceutical Co. Ltd.
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由岐 英剛
Department of Clinical Chemistry, School of Pharmaceutical Science, Toho University
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由岐 英剛
Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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鈴木 清吉
Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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鈴木 清吉
Research Laboratories Chugai Pharmaceutical Co. Ltd.
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高間 伸一
Research Laboratories Chugai Pharmaceutical Co. Ltd.
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由岐 英剛
Faculty Of Pharmaceutical Sciences Osaka University
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由岐 英剛
Department Of Clinical Chemistry School Of Pharmaceutical Science Toho University
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