Studies on Chemotherapeutic Agents.II. A Synthesis of Purine Nucleosides of _D-Glucuronic Acid
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概要
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Condensation of 4-ethylthio-5-nitro-6-chloropyrimidine with methyl 1-amino-1-deoxy-2,3,4-tri-O-acetyl-β-_D-glucopyranuronate was effectd to give methyl 1-deoxy-1-(4-ethylthio-5-nitro-6-pyrimidinylamino)-2,3-4-tri-O-acetyl-_D-glucopyranuronate (VI). Hydrogenation of nitro group of VI in the presence of platinum-catalyst and subsequent ring closure of 4,5-diamino-derivative (VII) with carbon disulfide were achieved. 6-Ethylthio group of X was replaced to 6-hydrazino group followed by treatment with Raney nickel to afford 1-deoxy-1-(6-amino-9-purinyl)-β-_D-glucopyranuronamide (XII). VII was reacted with sodium nitrite to give ν-triazolo derivative (XIII), 6-ethylthio group of which was readily aminated to yield 1-deoxy-1-(7-amino-3H-ν-triazolo [4,5-d] pyrimidin-3-yl)-β-_D-glucopyranuronamide (XIV).
- 公益社団法人日本薬学会の論文
- 1966-12-25
著者
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岸川 虎比古
Research Laboratories, Morishita Pharmaceutical Co., Ltd.
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由岐 英剛
Department of Clinical Chemistry, School of Pharmaceutical Science, Toho University
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由岐 英剛
Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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由岐 英剛
Faculty Of Pharmaceutical Sciences Osaka University
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由岐 英剛
Department Of Clinical Chemistry School Of Pharmaceutical Science Toho University
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岸川 虎比古
Research Laboratories Morishita Pharmaceutical Co. Ltd.
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