The Synthesis of 8-Substituted Purine Derivatives. I. Some 8-Substituted Derivatives of Hypoxanthine.
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概要
- 論文の詳細を見る
Some hypoxanthine derivatives which were substituted at C_8-position by hydrophilic groups such as-SH, -S-CH_2-COOH, -COOH, -CH_2OH and-CH_2-CH_2-COOH were synthesized for testing purine-antagonist action. They were prepared by condensation of 4,5-diamino-6-hydroxypyrimidine (I) with the corresponding acid or amide compounds through the acyl derivatives of (I). A direct preparation of 4-amino-6-hydroxypyrimidine by reaction of malonamamidine with ethyl formate was also described.
- 公益社団法人日本薬学会の論文
著者
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石館 守三
Pharmaceutical Institute, Medical Faculty, University of Tokyo
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石館 守三
Pharmaceutical Institute Medical Faculty University Of Tokyo
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由岐 英剛
Faculty Of Pharmaceutical Sciences Osaka University
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由岐 英剛
Pharmaceutical Institute, Medical Faculty, University of Tokyo
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由岐 英剛
Pharmaceutical Institute Medical Faculty University Of Tokyo
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