Regulation of Lithospermic Acid B and Shikonin Production in Lithospermum erythrorhizon Cell Suspension Cultures
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概要
- 論文の詳細を見る
Cell suspension cultures of Lithospermum erythrorhizon produced a large amount of lithospermic acid B, a caffeic acid tetramer, as well as shikonin derivatives (each ca. 10% of dry wt.) when cultured in shikonin production medium M-9. Various culture factors for increasing the production of lithospermic acid B were investigated. Lithospermic acid B production was inhibited by 2, 4-D or NH4+, whereas it was stimulated by Cu2+. These regulatory patterns were similar to those for the production of shikonin derivatives in these cell cultures, suggestive of close relations and similar metabolic regulation between the production of these compounds. Cultivation under light illumination, however, showed that these metabolisms were independently regulated. In particular, blue light showed a stimulatory effect on lithospermic acid B production, while shikonin production was strongly inhibited, indicative of an effective condition for lithospermic acid B production.
- 公益社団法人日本薬学会の論文
- 2002-08-01
著者
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Yazaki Kazufumi
Laboratory of Plant Gene Expression, Research Institute for Sustainable Humanosphere, Kyoto Universi
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Zhao P
Nagasaki Univ. Nagasaki Jpn
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Yazaki Kazufumi
Laboratory Of Gene Expression Wood Research Institute Kyoto University
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YAMAMOTO Hirobumi
Laboratory of Medicinal Plant Garden, Nagasaki University School of Pharmaceutical Sciences
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ZHAO Ping
Laboratory of Medicinal Plant Garden, Nagasaki University School of Pharmaceutical Sciences
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INOUE Kenichiro
Laboratory of Pharmacognosy, Gifu Pharmaceutical University
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Inoue K
Kobe Pharmaceutical Univ. Kobe Jpn
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Yamamoto Hirobumi
Laboratory Of Medicinal Plant Garden Nagasaki University School Of Pharmaceutical Sciences
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