Human MDR1 and MRP1 Recognize Berberine as Their Transport Substrate
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概要
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To examine whether human ATP-binding cassette (ABC) transporters play a role in the detoxification of plant alkaloid berberine, we investigated berberine transport using multidrug resistance protein1 (MDR1) and multidrug resistance-associated protein1 (MRP1). Cells expressing MDR1 or MRP1 accumulated less berberine. Berberine accumulation depended on the cellular ATP level, and was reversed by typical inhibitors of MDR1, suggesting that human MDR1 and MRP1 directly efflux berberine as their substrate.
- 社団法人 日本農芸化学会の論文
著者
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Yazaki Kazufumi
Laboratory of Plant Gene Expression, Research Institute for Sustainable Humanosphere, Kyoto Universi
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Ueda Kazumitsu
Laboratory Of Cellular Biochemistry Division Of Applied Life Sciences Graduate School Of Agriculture
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SHITAN Nobukazu
Laboratory of Plant Gene Expression, Research Institute for Sustainable Humanosphere, Kyoto Universi
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Tanaka Miyako
Laboratory Of Cellular Biochemistry Division Of Applied Life Sciences Faculty Of Agriculture Kyoto U
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TERAI Koichiro
Graduate School of Pharmaceutical Science, Kyoto University
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