ネズミ性機能に対するReserpineおよびモノアミンオキシダーゼ阻害剤の効果 : II.出生当初に発情ホルモンと並行投与された場合の成熟後の性機能

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Female rats which had been given reserpine or safrazine in their neonatal days revealed no evident change in their post-pubertal sexual activities. In the animals which received reserpine together with estrogen during the early postnatal period, vaginal records showed less markedly persistent estrus, particulary in the early postpubertal days, and the ovaries contained one set of the corpora lutea in almost all of the 70 days-animals. As compared with the animals given estrogen only, treatment with both estrogen and safrazine, although it exerted no noticeable effect on the smear records, consistently advanced the date of the first estrus and induced luteinization in some of the 150 days-animals. In the rats injected shortly after birth with a mixture of estrogen, reserpine and safrazine, sexual indices such as the times of vaginal canaliculization or intitial estrus, smear record, ovarian weight and percentage of luteinization, exhibited no difference from those of animals given estrogen and reserpine.
社団法人日本動物学会の論文
1974-06-25