ネズミ子宮および膣における発情ホルモンと雄性ホルモン間の相互作用

概要

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1) Adequate doses of testosterone propionate were capable of suppressing the action of estrone on the vagina, inducing intravaginal migration of leucocytes and impaiment of epithelial cornification. 2) Pateern of responses of vagina to simultaneous action of estrogen and androgen, as evidenced by changes in vaginal index, depicted a unimodal curve, while that to concurrent action of estrogen and progestogen, a bimodal curve (Maekawa, '60). 3) Prolongation of the duration of vaginal response to estrogen as induced by simultaneous administration of progesterone (Maekawa, '55) or 19-nortestosterone derivatives (Maekawa, Ito and Ikeda, '59), was not observable when testosterone propionate or androsterone wasadministered together with estrone. 4) Testosterone propionate was also effective in depressing the hysterotrophic effect of estrogen. The activity was quite comparable to that of progesterone. 5) Self-antagonism as observed between estrogenic and progestational potecies of ethihyl-nor-testosterone (Maekawa, '50) was not demonstrated between estrogenic and androgenic activities of ⊿^5-androstene-3β, 17β-dial or 17α-methyl-⊿^5-androstene-3β, 17β-dial.
社団法人日本動物学会の論文
1961-10-15