カドミウムの精巣破壊作用に対する血管拡張物質と血液凝固阻止物質の効果

概要

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The mechanism by which cadmium exerts profound injurious effects upon the testis has not yet been definitely worked out. In order to study whether the testicular damage caused by cadmium is due to a stagnation of intratesticular blood-flow, groups of adult male rats were given various vasodilators (apresoline, hexamethonium bromide, sodium nitrite and reserpine) or anticoagulants (heparin sodium and warfarin sodium), before and after cadmium injection and continued until the day of sacrifice. Although the weights of the testes in rats treated with apresoline, sodium nitrite or warfarin sodium in combination with cadmium exhibited a slight but definite increase over the weights in animals treated with cadmium only, histological studies did not reveal any protective effect of the drugs on the cadmium induced damage to the testes. In animals receiving warfarin together with cadmium, severe hemorrhage took place in the interstitial tissue of the testes and caput epididymides but not in any other tissues, showing that the primary effect of cadmium was exerted upon intratesticular or intraepididmal blood vessels. A similar hemorrhage did not occur in the testes of animals treated with warfarin only or cadmium only.
社団法人日本動物学会の論文
1967-01-15