ハツカネズミ膣上皮の発情ホルモンによる増殖と角質化に対する抗腫瘍物質の効果

概要

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Responses of the vaginal epithelium to antineoplastic compounds given concurrently with estrogen were studied. Female mice of dd strain were ovariectomized. Beginning on the 20th day after the operation, the animals were in injected daily with one of the following antineoplastic compounds, (methyl-bis (β-chloroethyl) amine-N-oxide hydrochloride, N, N', N''-triethylenethiophosphoramide, N, N-bis (β-chloroethyl)-N'O-propylene phosphoric acid ester diamide, mitomycin C, toyomycin, disodium salt of mercurihematoporphyrin or cobaltiprotoprophyrin), together with 0.2μg of estrone throughout 10 experimental days. During the course of experiment, vaginal smears were inspected daily, and perfect cornification of the vaginal epithelium was invariably revealed both in animals treated with estrone only and in those with estrone together with antineoplastic substance. Mitotic frequency in the vaginal epithelium of the mice receiving estrone and antineoplastic drugs, even when nearly lethal doses were administered, was almost the same with that of the mice receiving estrone only. Similarly, no significant difference was found between experimentals and controls in the weight and the epithelial height of the euterus.
社団法人日本動物学会の論文
1967-07-15