経口的に長期投与したカドミウムの精巣障害効果

概要

論文の詳細を見る
It is well established that a single injection of small amounts of cadmium selectively inflicts a damage on the testicular tissue, resulting in irreversible injury of the germinal epithelium. There are no reports, however, that cadmium is capable of inducing the similar testicular injury when it was administered orally for long period. An experiment was undertaken to clarify, therefore, why testicular injury is not observable in animals received chronic administration of cadmium. With continued feeding of male rats with cadmium chloride in amounts daily 9.0 mg per animal over a period of 300 days, authors observed, temporarily, a marked loss of testicular weight, a decrease of diameter of the seminal tubules and a fall of weight in the androgen -sensitive organs. During subsequent days, however, the animals were not responsive to cadmium showing a gradual recovery from the testicular injury despite continued administration of cadmium.
1968-02-15