ネズミ性機能に対するReserpineおよびモノアミンオキシダーゼ阻害剤の効果 : I.性成熟後に長期間単独または並行投与されたネズミの発情周期の変化

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Yaginal cycles in adult female rats injected subcutaneously with reserpine or safrazine or both reserpine and safrazine for 40 consecutive days were studied. In two groups of rats receiving larger (0.5mg/kg) and smaller (0.25mg/kg) daily dose of reserpine vaginal estrus was interrupted immediately after the beginning of injection, but despite continued administration, it recovered spontaneously soon after the anestrous period. Continuous administration of large (5.0mg/kg) and small (2.5mg/kg) doses of safrazine, on the contrary, induced slight but definitely prolonged setrus throughout the injection period. Safrazine, when it was given concurrently with reserpine, was capable of suppressing the effect of reserpine; animals which received both reserpine and safrazine revealed prolonged vaginal estrus as observed in rats injected with safrazine only.
社団法人日本動物学会の論文
1974-06-25