胎児期および乳児期に与えられたカドミウムの下垂体-精巣系に及ぼす効果

概要

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It is well established that in mammals administration of small amounts of cadmium salts selectively inflicts a damage on the testicular tissue, resulting in irreversible injury of the germinal epithelium. Since it is well known that the fetal and/or neonatal testis has a role in sexual differentiation of the genital accessories and of the secretion pattern of hypophyseal gonadotropins, it was attempted to study the effects of cadmium on the porphological and functional sex-defferetiation. Pregnant rats were given a single subcutaneous injection of 1.5mg cadmium chloride on the 14th, 16th or 18th day of gestation. Male and female rats born to and nursed by these mothers, however, were normal in the growth rate and in the age of sexual maturation. The gonads and the sexual accessories of these rats showed nothing different from those of the off-spring of non-injected mothers. The secretion pattern of gonadotropins by the anterior hypophysis was not affected; in subcutaneous ovarian grafts in orchidectomized males luteal formation failed to occur, while in similar grafts in ovariectomized females luteinization took place invariably.
1965-01-15