カドミウムの精巣障害効果とestrogen

概要

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Mechanism involved in the specific injurious action of cadmium on the testis has not been fully established. Parizek (1963, 1964) recently interpreted the cadmium effects as due to a lesion of capillary-regulating action of estrogen, postulating that cadmium primarily causes an impairment of estrogen-production by the testis, which in turn produces vascular damage in the testes resulting in a severe injury in the organ. In the present experiments, effects on the testis of estrogen administered concurrently with cadmium, and actions of cadmium on non-testicular estrogen-producing organs were studied. In male rats receiving a single subcutaneous injection of cadmium together with daily injections of large estrogen doses, the testes were severely injured as in animals given cadmium only. In female rats given a single injection of cadmium, the vaginal cycles were not interfered with even immediately after the injection, and the ovaries and adrenals, i.e. the estrogen-producing organs, were not significantly modified in structure. Furthermore, vaginal smears in female rats continuously given a large amount of cadmium in drinking water were normal in every respect, and the ovaries and adrenals of these rats were apparently healthy in microscopical structure. The results seem to show that estrogen has no bearing on the cadmium-injury in the testis.
社団法人日本動物学会の論文
1967-03-15